Prevalence of permanent numeric dental anomalies in panoramic radiography in an Iranian population

Aim: Dental number anomalies are a group of congenital developmental disorders divided into two groups supernumerary and missing teeth. This study was conducted to investigate the prevalence of numeric dental anomalies using panoramic images in patients referred to the Hamadan Dental Faculty. Methods: In this cross-sectional study, 2,197 panoramic radiographs of patients aged 6-49 years were evaluated. These anomalies are divided into two groups: 1) Supernumerary teeth, including Mesiodens, Distodens, and Peridens, and 2) Missing teeth, including Hypodontia, Oligodontia, and Anodontia. A Chi-square test was performed to assess the relationship between the anomalies. Data analysis was performed using SPSS 16, in which P-value < 0.05 was considered the statistical significance level. Results: Of 736 males (32.2%) and 1548 females (67.8%) in this study, 32 (4.3%) and 55 cases (3.8%) had supernumerary teeth, respectively. The prevalence of supernumerary teeth was 0.3%, 0.5%, and 0.6% in males and 0.2%, 1% and 1.2% in females for mesiodens, distodens, and peridens, respectively. Also, 243 males (10.6%) and 655 females (28.6%) had missing teeth anomalies. Hypodontia in the maxilla was the most common anomaly in both genders, while mesiodens was the least common. Conclusion: Hypodontia was the most common anomaly, followed by peridens; the least common anomaly was mesiodens. The prevalence of supernumerary teeth was greater in males, though the difference was not statistically significant. In comparison, females had a greater prevalence of missing teeth

X-linked hypohidrotic ectodermal dysplasia management with removable prosthesis in a pediatric patient: case report / Manejo de displasia ectodérmica hipohidrótica ligada al cromosoma X con prótesis removible en un paciente pediátrico: reporte de caso

Introduction: Ectodermal dysplasia is a rare genetic disorder that affects structures derived from ectoderm such as teeth, hair, nails, and sweat glands. Oligodontia is a common finding that affects the chewing, smiling and self- esteem of these pediatric patients. Case Report: We present a case report of a 7-years-old pediatric patient who consulted with his mother, showing the same condition. The intervention consisted of a removable prosthesis with satisfactory results. Conclusion: The X-linked hypohidrotic ectodermal dysplasia represents a challenge for a pediatric dentist who offers rehabilitation to the patient according to craniofacial development, age, socioeconomic status, and the number of missing teeth.

Introducción: La oligodoncia es un hallazgo común que afecta la masticación, la sonrisa y la autoestima de estos pacientes pediátricos. Case Report: Presentamos un reporte de caso de un paciente pediátrico de 7 años que consultó con su madre presentando la misma condición. La intervención consistió en una prótesis de remoción con resultados satisfactorios. Conclusión: La displasia ectodérmica hipohidrótica ligada al cromosoma X representa un desafío para un odontopediatra que ofrece rehabilitación al paciente de acuerdo con el desarrollo craneofacial, la edad, el nivel socioeconómico y el número de dientes faltantes.

Ectodermal Dysplasia in Primary Dentition – A Rare Case Report

Development of the primary and permanent dentition is a complex process wherein there is series of interactions between the ectoderm and ectomesenchyme. A cascade of signaling pathways occur in a spatio-temporal manner resulting in the development and eruption of the human dentition. Any developmental aberrations in shape, size, number, and position can lead to deviations from normal development of teeth. In this book, dental anomalies including gemination, fusion, concrescence, dilaceration, dens invaginatus, DE, taurodontism, enamel pearls, fluorosis, peg?shaped laterals, dentinal dysplasia, regional odontodysplasia and hypodontia etc. are discussed. Diagnosing dental abnormality needs a thorough evaluation of the patient and careful clinical and radiographical examination is required. Furthermore, more complex cases need multidisciplinary planning and treatment.

Therapeutic Possibilities for Maxillary Lateral Incisor Agenesis: a Literature Review / Possibilidades Terapêuticas para Agenesia de Incisivo Lateral Superior: uma Revisão de Literatura

Tooth agenesis or hypodontia is a developmental anomaly, where there is absence of one or more dental elements. The absence of maxillary lateral incisor can be uni or bilateral, has an incidence of 20% and is more frequent in females. Is directly related to the establishment of malocclusions and aesthetic dissatisfaction, so it is important to evaluate multidisciplinary parameters for a treatment decision. The objective of the present study is to establish, according to the present literature, clinical criteria for the therapeutic approach of opening or closing dental space of the Maxillary Lateral Incisor Agenesis. A systematized literature review was carried out in online databases: PubMed, Embase and Lilacs. Health descriptors and free terms were combined with Boolean operators to search: "Tooth Agenesis" or "Anodontia" and "Lateral Incisors" and "Treatment" and "Opening Space" or "Space Closure". Clinical studies that presented diagnostic criteria and therapeutic possibilities for Maxillary Lateral Incisor Agenesis, in English and without publication time frame, were included. During the clinical examination, skeletal, dental and periodontal parameters must be carefully observed. The intervention will always consist of a multidisciplinary approach, which may involve orthodontics, prosthetics, dentistry, periodontics and implantology for functional and aesthetic rehabilitation. The interceptive approach is based on early diagnosis and maintenance of the dental space, so orthodontic corrective treatment can be minimized later on. Late intervention includes closing the space with the reanatomization of adjacent dental elements or opening the space for implant and prosthesis installation. (AU)

A agenesia dentária ou hipodontia é uma anomalia de desenvolvimento, onde há ausência de um ou mais elementos dentários. A ausência do incisivo lateral superior possui uma incidência de 20%, mais frequente no sexo feminino e pode ser unilateral ou bilateral e estão diretamente relacionadas ao estabelecimento de maloclusões e insatisfação estética, assim, é importante que os profissionais saibam avaliar os parâmetros multidisciplinares para uma tomada de decisão sobre seu tratamento. O objetivo do presente estudo é estabelecer, segundo a literatura presente, os critérios clínicos para a tomada de decisão terapêutica de abertura ou fechamento de espaço para a Agenesia de Incisivo Lateral Superior. Foi realizada uma Revisão Sistematizada da Literatura nas bases de dados online: PubMed, Embase e Lilacs. Foram combinados descritores em saúde e termos livres com operadores boleanos para realizar a pesquisa nas bases de dados: "Tooth Agenesis" or "Anodontia" and "Lateral Incisors" and "Treatment" and "opening space" or "space closure". Foram incluídos estudos clínicos que apresentaram critérios para o diagnóstico e possibilidades terapêuticas para a Agenesia do Incisivo Lateral Superior, na língua inglesa e sem recorte temporal de publicação. Durante o exame clínico devem ser observados minuciosamente os parâmetros esqueléticos, dentários e periodontais. A intervenção sempre consistirá na abordagem multidisciplinar, podendo envolver ortodontia, prótese, dentística, periodontia e implantodontia para a reabilitação funcional e estética. A abordagem interceptativa consiste em diagnosticar precocemente e manter o espaço dentário, para que possa minimizar terapias ortodônticas corretivas de maior magnitude posteriormente. A intevenção tardia engloba o fechamento do espaço com a reanatomização dos elementos dentários adjacentes e abertura do espaço para instalação de implante e prótese. (AU)

Agenesias dentárias atípicas: relato de caso clínico / Atypical dental agenesis: clinical case report

A agenesia dentaria é uma anomalia de desenvolvimento caracterizada pela determinação congênita de menor numero de dentes, podendo estar associada a síndromes genéticas ou ocorrer isoladamente. Embora seja considerada uma das anomalias mais frequentes quando envolve terceiros molares, segundo pré-molares e incisivos laterais, sua ocorrência em dentes estáveis, tais como o canino e o primeiro molar permanente é rara. Desta forma, este relato apresentará o caso de uma paciente do sexo feminino, 8 anos idade, que iniciou tratamento de rotina na Clínica de Odontopediatria da UNIFENAS. Na anamnese não foi relatada pela responsável a ocorrência de alterações sistêmicas, nem queixa ou histórico odontológico relevante. No exame clínico odontológico, notou-se o não irrompimento do primeiro molar permanente superior direito (16). Diante dos exames de imagem, foi confirmada a agenesia do dente 16 e também do canino permanente superior direito (13). A agenesia, sobretudo de dentes estáveis e relevantes no arco dentário, pode comprometer o desenvolvimento adequado da oclusão, mastigação, fonação e estética. Desta maneira, é importante o diagnóstico precoce desta ocorrência com o objetivo de favorecer a elaboração de um adequado plano de tratamento e, minimizar as sequelas destas agenesias atípicas(AU)

Dental agenesis is a developmental anomaly characterized by the congenital determination of fewer teeth, may be associated with genetic syndromes or occur in an isolated form. Although it is considered one of the most frequent anomalies when it involves third molars, second lateral premolars and incisors, the occurrence in stable teeth, such as the permanent canine and the permanent first molar is rare. This report will present the case of an 8-year-old female patient who started routine treatment at the Pediatric Dentistry Clinic of UNIFENAS. In the anamnesis, the responsible person did not report the occurrence of systemic alterations, or a relevant dental complaint or history. On dental clinical examination, it was noticed the non-rupture of the permament maxillar right first molar (16). In view of the imaging tests, the agenesis of tooth 16 and also of the permanent maxillary right canine (13) was confirmed. Agenesis, especially of stable and relevant teeth in the dental arch, may compromise the proper development of occlusion, chewing, phonation and aesthetics. Thus, it is of paramount importance to early diagnosis of this occurrence in order to favor the development of an appropriate treatment plan in order to minimize the sequelae of these atypical agenesis(AU)

Novel mutations identified in the WNT10A gene and implant rehabilitation of patients with severe tooth agenesis / 口腔疾病防治

Objective@#To detect WNT10A gene mutations in patients with oligodontia or anodontia (≥6 teeth missing) and analyze their dental phenotype. @*Methods@#Patients with oligodontia or anodontia were enrolled from the clinic for oral examination, genetic history collection and whole exon sequencing, and patients with WNT10A gene mutations were included. Sanger sequencing was utilized to validate the WNT10A gene variations in probands and family members compared with the normal sequence. The pathogenicity of WNT10A mutations was evaluated by functional prediction, conservation analysis and structure prediction of protein mutants. Implant rehabilitation was applied to restore the patients' oral function.@*Results@# Five WNT10A gene mutations were detected in six unrelated patients, and c.26G>A (p. Trp9X) and c.1036delT (p. Cys346fs) were novel mutations with pathogenic potential. The mean number of missing teeth was (15.33±8.64) per case. The most frequently missing permanent teeth were maxillary canines (100%), and the least frequently missing teeth were mandibular first molars (25%). Implant rehabilitation was applied in five patients, and patients were found to have ideal implant osseointegration and functional restoration.@*Conclusion @# This study identified novel WNT10A gene pathogenic variants, enriching the WNT10A gene spectrum and providing new evidence for genetic diagnosis and prenatal consultation. Implant rehabilitation was also proven to be a treatment option for these patients.

Prosthetic dental management of a patient with anhidrotic ectodermal dysplasia: a case report / Manejo protésico dental de un paciente con displasia ectodérmica anhidrótica: reporte de caso

Introduction: Ectodermal dysplasia (ED) comprises a broad group of genetic disorders characterized by alterations of the structures derived from the ectoderm, including those of the stomatognathic system. Case Report: The present article aims to report the prosthetic management of a patient with anhidrotic ectodermal dysplasia. A male patient diagnosed with ED who attended the dental consultation displaying oligodontia; underdeveloped alveolar ridges were observed. Results: The established treatment consisted of the adaptation of implant-supported fixed full-arch prosthesis designed through CAD-CAM technology for the lower jaw and of a removable partial prosthesis with muco-dental support for the upper jaw. The dental approach of patients with ED is based on a correct analysis of the facial characteristics and stomatological conditions of each subject. Conclusion: A multidisciplinary approach is mandatory due to the biological and functional complexity in biomechanical terms of these individuals.

Introducción: La displasia ectodérmica (DE) comprende un amplio grupo de trastornos genéticos caracterizados por alteraciones de las estructuras derivadas del ectodermo, incluidas las del sistema estomatognático. Reporte de Caso: El presente artículo tiene como objetivo informar del manejo protésico de un paciente con displasia ectodérmica anhidrótica. Paciente varón diagnosticado de DE acudió a consulta odontológica por oligodoncia; Se observaron crestas alveolares subdesarrolladas. Resultados: El tratamiento establecido consistió en la adaptación de una prótesis de arcada completa fija implantosoportada diseñada mediante tecnología CAD-CAM para el maxilar inferior y de una prótesis parcial removible con soporte muco-dental para el maxilar superior. El abordaje odontológico de los pacientes con DE se basa en un correcto análisis de las características faciales y condiciones estomatológicas de cada sujeto. Conclusión: Un enfoque multidisciplinario es obligatorio debido a la complejidad biológica y funcional en términos biomecánicos de estos individuos.

Caracterización morfológica de caninos en premolares, un caso de anodoncia parcial de caninos maxilares / Morphological characterization of canine teeth done in first bicuspid, a maxillary canine partial anodontia case report

En este informe de caso clínico se muestra el tratamiento exitoso de un paciente con anodoncia parcial de órganos dentales 13 y 23 debido a que fueron extraídos por presentar impactación y mal pronóstico de tracción. En este artículo se presenta un paciente masculino de 29 años clase I esquelética con un perfil convexo, maloclusión de clase III, overjet disminuido, ausencia de guías funcionales, discrepancia oseodentaria positiva en arcada superior y negativa en arcada inferior. El tratamiento se realizó con extracciones de los órganos dentales 34 y 44 para nivelar las discrepancias óseo dentarias interarcadas, se llevó a cabo mediante un cierre de espacios recíproco por medio de cadenas elásticas para ambas arcadas, con lo que se logró crear un overjet y overbite adecuados. La creación de las guías caninas funcionales se consiguió mediante el cambio de morfología de los órganos dentales 14 y 24, los cuales fueron llevados a la posición de los caninos ausentes. El tiempo total de tratamiento para este paciente fue de 24 meses. Se realizaron ameloplastias positivas, la aplicación de agregados de resina para mejorar la funcionalidad y proveer salud articular. Se sugiere que ante casos de anodoncia de caninos en la arcada superior, un tratamiento favorable se puede llevar a cabo mediante el cierre de espacios, la caracterización morfológica de los caninos ausentes mediante ameloplastias positivas en premolares (AU)

This case report shows the successful treatment of a patient with partial anodontia of dental organs 13 and 23 because they have been extracted due to present impactation and poor traction prognosis. This article presents a 29-year-old male class I skeletal patient with convex profile, class III malocclusion, overjet reduction, absence of functional guidance, positive bone-teeth discrepancy in the upper arch and negative in the lower arch. The treatment was carried out with the extractions of the dental organs 34 and 44 for correcting oral dental discrepancies between upper and lower arches; it was done using reciprocal closing of spaces by using elastic chains for both arches in order to achieve a suitable overjet and overbite. The creation of the canine guides was achieved by changing the morphology of the dental organs 14 and 24, which were taken to the position of the absent canines. The total treatment timing for this patient was 24 months. Positive ameloplasties were performed by application of resin aggregates to improve functionality and provide joint health. A favorable treatment for these kinds of cases of canine anodontics in the upper arch is carried out by closing spaces and the morphological characterization of the absent canines by positive in-premolar ameloplasties (AU)

Radiographic Assessment of Third Molars Agenesis Patterns in Young Adults

ABSTRACT Objective: To determine the prevalence of third molar agenesis and associated characteristics. Material and Methods: A total of 2374 panoramic radiographs were retrieved from the radiological archives and evaluated in a computer monitor under optimum viewing conditions. The basic demographic data (age and sex) and the primary findings regarding the presence or absence of third molars in the maxillary and mandibular arches were recorded systematically in a specially designed proforma. Categorical variables were compared using the Chi-square test. Results: A total of 2000 panoramic radiographs were included in the study, of which 1004 were females (50.2%), and 996 were of males (49.8%). The incidence of third molar agenesis was 486 patients (24.3%). Maxillary third molar showed a higher prevalence of agenesis (28.8%) than mandibular third molars (16.4%). A total of 1514 patients (75.7%) had third molars in all four quadrants, and the remaining 486 patients (24.3%) had agenesis of third molar tooth in at least one of the quadrants. Single tooth agenesis was observed in 219 (11%) patients, two teeth agenesis in 172 (8.6%) patients, three teeth agenesis in 39 (2%) patients, and four teeth agenesis in 56 (2.8%) patients. Conclusion: The present study exhibited a maximum number of single tooth agenesis. It was also observed that maxillary third molar agenesis is more than the mandibular third molar and the right side is more than the left side. Agenesis of the third molar is more prevalent in males as compared to females.

Radiographic examination in the diagnosis of a curious case associating odontoma to agenesis and supernumerary teeth / O exame radiográfico no diagnóstico de um caso curioso associando odontoma à agenesia e dente supranumerário

ABSTRACT Developmental disorders of human dentition may result in various abnormalities according to etiologic agents and the developmental period involved. The size, shape and number of teeth may be affected. Dental abnormalities can occur singly or in multiples in an individual and may or may not be associated with syndromes. Complementary radiographic examinations are valuable for diagnosis, especially in lesions that are asymptomatic and detected only through examination. The present study is intended to report a case of an incidental finding in panoramic radiography of an odontoma, a supernumerary tooth and permanent tooth agenesis in the same non-syndromic individual. According to the literature, the association of hypodontia and hyperdontia (called concomitant hypo-hyperdontia) is most common. The association of hyperdontia and odontoma is uncommon but still reported. However, regarding the association of hypodontia and odontoma no reports were found, as well as the association of the three pathologies.

RESUMO Os distúrbios de desenvolvimento da dentição humana podem resultar em diferentes anomalias dependendo do agente etiológico e do período do desenvolvimento acometido. O tamanho, a forma e o número dos dentes, dentre outros, podem ser afetados. Podem ocorrer isoladamente ou em conjunto num mesmo indivíduo, bem como estarem ou não associados a síndromes. Os exames radiográficos complementares são valiosos para o diagnóstico, sobretudo quando as lesões são assintomáticas e detectadas incidentalmente no exame. O presente trabalho relata o caso de achado incidental, em radiografia panorâmica, de odontoma, dente supranumerário e agenesia de dente permanente num mesmo indivíduo não sindrômico. Segundo relatos da literatura, a associação de hipodontia e hiperdontia, denominada hipo-hiperdontia concomitante, é a mais comumente encontrada. A associação de hiperdontia e odontoma é incomum, mas ainda é relatada. No entanto, a respeito da associação de hipodontia e odontoma não foram encontrados relatos, bem como da associação das três patologias.

Association between tooth agenesis and cancer: a systematic review

Abstract The congenital absence of multiple teeth may share the same genetic background of the development of some types of cancer. Objective: This systematic review aimed to investigate the possible association between dental agenesis and cancer, and the perspective of agenesis as an early predictor for cancer risk. Methodology: The electronic databases PubMed, Scopus, Web of Science, Cochrane Library, LILACS, and OpenGrey were searched and the risk of bias was evaluated using the Newcastle-Ottawa tool. The GRADE tool was used to evaluate the certainty of the evidence. Results: Six studies met the eligibility criteria. A positive co-occurrence between ovarian cancer and hypodontia was found in two articles. Three studies evaluated the association between dental agenesis and colorectal cancer and only one showed common genes for these conditions. One paper found individuals with hypodontia had a higher risk of family history of cancer. Five studies had a fair quality and one a good quality. The certainty of evidence was classified as very low. Conclusion: Notwithstanding the limited scientific evidence, there may be a possible association between dental agenesis and cancer due to genes involved in both conditions. Agenesis of multiple teeth could be an early indicator of cancer risk. Nevertheless, studies with a better level of evidence are needed to confirm this possible association.

Odontoma complejo y quiste dentígero concurrentes asociados a retención dentaria / Concurrent occurrence of complex odontoma and dentigerous cyst associated to tooth retention

RESUMEN Los dientes retenidos pueden asociarse a enfermedades de diversa índole con complicaciones: mecánicas, nerviosas, infecciosas, quísticas y tumorales. El objetivo de esta investigación es informar un caso de quiste dentígero y odontoma concurrentes, asociados a un canino superior retenido. Se presentó un paciente de 15 años que acudió al Servicio de Cirugía Maxilofacial de la Facultad de Estomatología, con evidente aumento de volumen en la superficie vestibular de reborde alveolar superior en la zona del 13, y desplazamiento progresivo coronal distal del 12. Se realizaron: interrogatorio, examen clínico y estudio radiográfico; se observó retención del 13, con asociación de área radiopaca redondeada definida y con área radiolúcida circunscrita. Se realizó una biopsia de los tejidos descritos y se obtuvo un diagnóstico de quiste dentígero y odontoma complejo. El fenómeno de retención dentaria aparece de forma concomitante con otras lesiones que pueden producir destrucción ósea y desorden de posición y número.

ABSTRACT Retained teeth can be associated with a variety of diseases with mechanical, nervous, infectious, cystic and tumoral complications. The aim of this research is to report a case of concurrent dentigerous cyst and odontoma, associated with a retained upper canine. We present a 15-year-old patient who comes to the Maxillofacial Surgery Service from the Dental Faculty due to an evident volume increase in the vestibular surface of the maxillary alveolar ridge in 13 area, and progressive distal coronal displacement of 12. An interview, a clinical examination and a radiographic study were performed; tooth retention of 13 was observed, with association of defined rounded radiopaque area and circumscribed radiolucent area. A biopsy of the described tissues was performed and a diagnosis of dentigerous cyst and complex odontoma was obtained. The phenomenon of tooth retention appears concomitantly with other lesions that can produce bone destruction and disorder of position and number.

Association between hypodontia of permanent maxillary lateral incisors and other dental anomalies

ABSTRACT Introduction: Tooth agenesis is often associated with other tooth anomalies, such as microdontia, delayed eruption and ectopic eruption. Moreover, they may be found all in the same individual, as certain genetic mutations may have a variable phenotypic expression. Treatment of cases of hypodontia of anterior teeth should not involve only opening or closing space for prosthetic rehabilitation. Individuals with hypodontia of permanent maxillary lateral incisors may have teeth with a mesiodistal width smaller than that of patients with a normal dentition, and which may need reshaping to achieve an esthetic and functional occlusion. Objective: This clinical case report discusses the association of hypodontia of permanent maxillary lateral incisors with other tooth anomalies and their treatment alternatives.

RESUMO Introdução: As agenesias dentárias são frequentemente associadas a outras anomalias dentárias, tais como microdontia, atraso na erupção e ectopismo. Além disso, podem vir todas juntas em um mesmo indivíduo, pois certas mutações genéticas podem se expressar fenotipicamente de diferentes formas. A abordagem terapêutica nos casos de hipodontia de dentes anteriores não deve se pautar somente entre fechar ou abrir espaço para substituição protética. Portadores de hipodontia de incisivos laterais superiores permanentes podem apresentar os outros dentes com largura mesiodistal menor que os de pacientes com dentição normal, e podem necessitar de reanatomizações para que se obtenha uma oclusão dentária estética e funcional. Objetivo: Dessa forma, o objetivo do presente artigo é relatar um caso clínico e discutir a associação da hipodontia de incisivos laterais superiores permanentes com outras anomalias dentárias, e suas alternativas de tratamento.

Prevalencia de agenesia dental en pacientes evaluados en ortodoncia, Santiago de Chile / Prevalence of dental agenesis in patients evaluated in orthodontics, Santiago de Chile

Resumen La agenesia dentaria es una anomalía frecuente de detectar en un examen odontológico. Objetivo: Determinar la prevalencia de agenesias en la población chilena actual, comparar según sexo, diente afectado y clase esqueletal, y registrar microdoncia de incisivos laterales superiores permanentes. Materiales y métodos: En este estudio descriptivo transversal, se contabilizó el número de agenesias dentarias presentes en 278 radiografías panorámicas de un total de 9207 pacientes, que ingresaron a tratamiento de ortodoncia durante el año 2017 en un centro clínico privado de Santiago de Chile. Resultados: Se obtuvo una prevalencia de agenesia del 3,02%, encontrando una mayor frecuencia de agenesia de segundos premolares inferiores, seguido de incisivos laterales superiores. Hubo una mayor cantidad de agenesias en pacientes de sexo femenino. Conclusión: Los segundos premolares son los dientes con mayor prevalencia de agenesias, no se evidenció la asociación de agenesias en alguna clase esqueletal específica, y se sugieren más estudios para describir la prevalencia de los terceros molares, debido a que este diente está en vías de dejar desarrollarse, según la teoría evolutiva.

Abstract Dental agenesis is a frequent anomaly detected in a dental examination. Objective: To determine the prevalence of agenesis in the current Chilean population, compare according to sex, affected tooth, skeletal class, and record microdontia of permanent upper lateral incisors. Materials and methods: In this cross-sectional descriptive study, the number of dental agenesis present in 278 panoramic radiographs of a total of 9207 patients who entered orthodontic treatment during 2017 in a private clinical center in Santiago de Chile was recorded. Results: A prevalence of agenesis of 3.02% was obtained, finding a higher frequency in lower second premolars, followed by upper lateral incisors. Females presented a higher amount of cases in comparison to males. Conclusion: The second premolars are the teeth with the highest prevalence of agenesis. The association of this alteration with some specific skeletal class was not evidenced. More studies are suggested to describe it´s prevalence in the third molars, beacause according to the evolutionary theory this tooth might eventually disappear.

Agenesis of third molars and its association with other dental anomalies in a peruvian population / Agenesia de terceros molares y su asociación con otras anomalías dentales en una población peruana

Objective: The purpose of the present study was to determine the association between agenesis of the third molar and other dental anomalies. Materials and Methods: This was an observational, retrospective, cross-sectional and analytical study. The sample included 367 patients, aged 14 to 20 years old with adequate digital panoramic radiography. Patients with syndromes, who had extractions of any third molar and with orthodontic treatment prior to panoramic radiographic examination, were excluded. For data collection, each radiograph was recorded with patient code, sex and age. Results: The prevalence of third molar agenesis was 20.71%. Subsequently, patients were divided into two groups, with agenesis of at least one third molar and a control group; the prevalence of other dental anomalies was 48.69% of third molar agenesis group and 21.31% in the control group. A highly significant association was found between the presence of third molar agenesis and the presence of other tooth abnomalities (p= 0.0000; contingency coefficient = 0.2425).The most frequent dental anomaly was dental inclusion with 20.44% of the population studied; followed by the agenesis of other teeth (7.90%) and finally the presence of supernumerary teeth (1.63%). Conclusions: This study demonstrates that there is an association between third molar agenesis and other dental abnormalities, with a higher prevalence of dental abnormalities in patients with third molar agenesis.

Objetivo: La presente investigación tuvo como finalidad determinar la asociación que existe entre la agenesia del tercer molar y otras anomalías dentarias. Material y Métodos: El estudio fue observacional, retrospectivo, transversal y analítico. La muestra que incluyó 367 pacientes de 14 a 20 años de edad con radiografía panorámica digital con parámetros adecuados. Se excluyeron pacientes con algún tipo de condición sindrómica, con exodoncias de algún tercer molar y con tratamiento ortodóntico previo al examen radiográfico panorámico. Para la recolección de datos, cada radiografía fue registrada con código de paciente, sexo, edad. Resultado: Se reportó una prevalencia de 20,71% de casos con agenesia de terceros molares. Los pacientes fueron divididos en 2 grupos, con agenesia de al menos un tercer molar y un grupo control, en ambos se calculó la prevalencia las otras anomalías dentarias, la cual fue de 48.69% de los pacientes que presentan agenesia de tercer molar tienen otra anomalía dentaria y 21.31% del grupo control tienen otra anomalía dentaria. Se encontró una asociación altamente significativa entre la presencia de agenesia de tercer molar y presencia de otras anomalías dentales (p=0.0000; coeficiente de contingencia=0.2425). La anomalía dental encontrada con más frecuencia es la inclusión dentaria con 20,44% del total de la población estudiada; seguido de la agenesia de otros dientes con 7,90% y finalmente la presencia de dientes supernumerarios con 1,63%. Conclusion: Este estudio demuestra que existe asociación entre la agenesia de tercer molar y otras anomalías dentarias, existiendo una mayor prevalencia de anomalías dentales en pacientes con agenesia del tercer molar.

Prevalence of dental anomalies and bone alterations in childrens panoramic radiographies / Prevalência das anomalias dentárias e alterações ósseas em radiografias panorâmicas de crianças

ABSTRACT Objective To verify the prevalence of dental anomalies in terms of number, position and shape, and the presence of bone alterations, through analysis of panoramic radiographs. Methods This study evaluated dental anomalies and bone alterations in children aged 6 to 12 years-old, detected on panoramic radiographies recorded in the radiographic database of the Federal University of Espírito Santo between 2012 and 2016. Clinical and demographic information were registered. Dental records were retrieved to obtain the medical history involving syndromes or other diseases that may interfere with the anomalies and alterations. Chi-square and exact Fischer's statistical tests were performed. Results There were alterations in 83 out of 301 panoramic radiographs analyzed. There were 169 anomalies or alterations (mean of 2,04±1,38 anomalies/patient), involving 201 teeth. The most prevalent anomaly was tooth impaction (26.63%), which affected the canines more frequently, followed by hypodontia (24.26%), more often found in the second premolar, and both affected mostly females. Hyperdontia and radiolucent lesions showed the same prevalence (18.93%), the most affected teeth were those of the anterosuperior region and the first mandibular molars, respectively. The least prevalent anomalies were dilaceration (7.69%), taurodontism (2.37%) and radiopaque lesions (1.18%). Bone alterations were significantly more found in mandible and in the posterior region, which confirms the prevalence in the lower molars. Conclusion Although there was no statistically significant difference regarding sex, there was a high prevalence of anomalies and alterations in our study population, which indicates the importance of its diagnosis by means of a panoramic x-ray examination.

RESUMO Objetivo Verificar a prevalência das anomalias dentárias de número, posição e forma, além da presença de alterações ósseas, por meio de radiografias panorâmicas. Métodos Levantamento das anomalias dentárias e alterações ósseas em crianças de 6 a 12 anos, com radiografia panorâmica registrada no Banco de Imagens Radiográficas da Universidade Federal do Espírito Santo nos anos de 2012 a 2016. Foram registradas informações clínico-demográficas referentes aos pacientes atendidos. As fichas clínicas foram recuperadas para obtenção da história médica de síndromes ou outras doenças que interfiram nas anomalias e alterações. Foram realizados os testes estatísticos qui-quadrado ou exato de Fischer. Resultados Foram encontradas 83 radiografias panorâmicas que mostravam algum tipo de alteração em 301 analisadas. Foram descritas 169 anomalias ou alterações (média de 2,04±1,38 anomalias/paciente), envolvendo 201 dentes. A anomalia mais prevalente foi a impactação (26,63%) que afetou mais os caninos, seguida da hipodontia (24,26%) que ocorreu mais em segundos pré-molares, em ambas o sexo feminino foi mais acometido. A hiperdontia e as lesões radiolúcidas tiveram a mesma prevalência (18,93%), os dentes mais acometidos foram da região ântero-superior e os primeiros molares inferiores, respectivamente. As menos prevalentes foram dilaceração (7,69%), taurodontia (2,37%) e lesões radiopacas (1,18%). As anomalias ósseas estavam significativamente mais em mandíbula e na região posterior, o que confirma a prevalência em molares inferiores. Conclusão Não houve diferença estatisticamente significativa em relação ao gênero. Mas houve alta prevalência de anomalias e alterações na população estudada, o que denota a importância do diagnóstico por meio desse importante exame complementar.

Genetic polymorphism in ESR2 and risk of tooth agenesis

Introduction: Tooth agenesis (TA) is the congenital absence of teeth. Several studies have proposed a strong genetic background for this condition. Aim: The present cross-sectional study aimed to evaluate whether genetic polymorphisms in the genes that code for estrogen receptors ( ESR1 and ESR2 ) are associated with the presence of isolated TA in a Brazilian sample. Methods: Panoramic radiographs of 142 orthodontic patients were assessed to determine TA of permanent teeth (excluding third molars). DNA of patients was extracted from buccal cells from saliva to evaluate genetic polymorphisms in ESR1 ( rs2234693 and rs9340799 ) and ESR2 ( rs1256049 and rs4986938 ) by genotyping using the real-time PCR technique. For statistical analyses, associations between the distributions of the alleles and genotypes, and the ocurrence of TA were assessed for each genetic polymorphism, with an established alpha of 5%. Results: Thirteen patients had at least 1 congenital missing tooth. The number of congenitally missing teeth ranged from 1 to 11. The genetic polymorphisms rs2234693 and rs9340799 in ESR1 and rs1256049 in ESR2 were not associated with TA ( p > 0.05) . For the genetic polymorphism rs4986938 in ESR2, the genotype and allele distributions were significantly different between the patients with and without TA ( p < 0.05). The CC genotype and the C allele were overrepresented in the TA patients. Conclusion: The genetic polymorphism rs4986938 in ESR2 was associated with the ocurrence o f TA.

Introdução: A agenesia dentária (AD) é a ausência congênita de um ou mais dentes. Vários estudos vêm sugerindo o forte componente genético para essa condição. Objetivo: O presente estudo teve como objetivo avaliar se os polimorfismos genéticos nos genes que codificam os receptores de estrógeno ( ESR1 e ESR2 ) estão associados à ocorrrência de AD isolada em uma amostra brasileira. Métodos: Radiografias panorâmicas de 142 pacientes ortodônticos foram avaliadas para determinar AD de dentes permanentes (excluindo terceiros molares). O DNA dos pacientes foi extraído das células da mucosa bucal contidas na saliva para avaliar polimorfismos genéticos em ESR1 ( rs2234693 e rs9340799 ) e ESR2 ( rs1256049 e rs4986938 ) por genotipagem usando a técnica de PCR em tempo real. Para análises estatísticas, associações entre as distribuições dos alelos e genótipos e a ocorrrência de AD foram avaliadas para cada polimorfismo genético, com um alfa estabelecido de 5%. Resultados: Treze pacientes tiveram pelo menos 1 dente congenitamente ausente. O número de dentes congenitamente ausentes variou de 1 a 11. Os polimorfismos genéticos rs2234693 e rs9340799 no ESR1 e rs1256049 no ESR2 não foram associados à AD ( p > 0,05). Para o polimorfismo genético rs4986938 no ESR2 , as distribuições dos genótipos e dos alelos foram estatisticamente diferentes entre os pacientes com e sem AD ( p < 0,05). O genótipo CC e o alelo C estavam super-representados nos pacientes com AD. Conclusão: Houve associação entre o polimorfismo genético rs4986938 no ESR2 e a ocorrrência de AD.

Are Environmental Factors Effective in Congenitally Missing Teeth? A Multicenter Study

Abstract Objective: To examine the prevalence of congenital absence of permanent teeth other than third molar teeth in non-syndromic children in the Black Sea and Mediterranean Regions of Turkey, and the correlation between gender and distribution sites in the jaws. Material and Methods: Panoramic radiographs and clinical records of 9831 children (5025 girls, 4806 boys) in the Mediterranean Region and 11372 children (5540 girls, 5832 boys) in the Black Sea region were examined. All panoramic radiographs were evaluated by a dentist. The permanent tooth, which was not seen in radiography, was recorded as a congenitally missing tooth, and the fact that the tooth was not extracted was confirmed by treatment records. The data were statistically evaluated by Chi-Square and t-test Results: The prevalence of congenitally missing permanent teeth was 2.8% (3.52% in girls, 2.5% in boys) in the Mediterranean region and 1.63% (1.82% in girls and 1.45% in boys) in the Black Sea region. Congenitally missing permanent teeth were observed more in the maxilla compared to mandible. The teeth that most frequently have congenitally missing permanent teeth in the Mediterranean Region are mandibular second premolars, maxillary lateral incisors and maxillary second premolars, respectively. The teeth that most frequently have congenitally missing permanent teeth in the Black Sea region are mandibular second premolars, maxillary second premolars and maxillary lateral incisors, respectively. Most of the patients had one or two teeth missing, and the lack of three or more teeth was rare Conclusion: In this study, which is performed in different climatic characteristics of Black Sea and Mediterranean Regions, the frequency of congenitally missing teeth is similar.

Prevalence of Dental Anomalies in Indonesian Individuals with Down Syndrome

Abstract Objective: To determine the frequency distribution of dental anomalies in people with Down syndrome. Material and Methods: This cross-sectional study was developed in Jakarta, Indonesia, and evaluated 174 individuals with Down syndrome aged 14-53 years. Were collected information regarding the tooth number, tooth size, shape, and structure. Descriptive statistics were used to calculate the absolute and relative frequencies. The Pearson chi-square test was used in bivariate analysis. The significance threshold was set at 5% Results: There were 70 female subjects (40.2%) and 104 male subjects (59.8%) with an average age of 19.2 years. In terms of anomalies of tooth number, hypodontia (80.9%), supernumerary teeth (12.4%), and combined hypodontia and supernumerary teeth (12.4%) were identified. In terms of anomalies of tooth size, microdontia (98.8%) is the most common anomaly. Anomalies of tooth shape included fusion (66.67%) and talon's cusp (33.3%), whereas anomalies of tooth structure included enamel hypoplasia (70.8%), enamel hypocalcification (4.2%), combined enamel hypoplasia and hypocalcification (12.5%), and tooth discoloration (12.5%) Conclusion: Individuals with Down syndrome in Jakarta showed a high prevalence of dental anomalies, with hypodontia and microdontia being the most common anomalies showing a tendency to occur predominantly in males.

Digital smile designing, pressing and stratifying ceramic lithium disilicate veneers to rehabilitate dental agenesis: a clinical report / Facetas cerâmicas de dissilicato de lítio estratificadas e prensadas para reabilitação de agenesia dental com digital smile design: relato de caso

ABSTRACT This article had the objective of reporting a case of aesthetic rehabilitation with laminated facets from the 14 to the 24 teeth made with IPS E.max Ceram ceramics (Ivoclar-Vivadent), which replaced previous unsatisfactory composite resin restorations in the anterior region. The patient had agenesis of 12 and 22 teeth, making it necessary to anatomize the anterior teeth. A digital smile design was first virtually created and then followed by a diagnostic wax-up. The following was performed in a single day: periodontal surgery using the flapless technique to achieve prosthetic space; teeth preparation; an additionalsilicone impression; and multiple provisional restorations of bis-acryl composite resins were fabricated. Fourteen days later, in the second session the ceramic veneers were etched with 5% hydrofluoric acid for 20s; they received a silane application and a silane heat treatment, then lastly an ultrasonic bath. A universal adhesive was used in combination with a light curing cement.Cementation was performed immediately following an occlusal adjustment. The patient returned for a follow-up appointment another fourteen days after the luting process, in which a further occlusal adjustment was performed, and he reported complete satisfaction with the treatment.

RESUMO Este é um relato de caso de reabilitação estética anterior com facetas laminadas dos elementos 14 ao 24 confeccionadas com a cerâmica IPSE.max Ceram (Ivoclar -Vivadent), as quais substituíram facetas de resina composta insatisfatórias dos elementos 13 ao 23. Ressalta-se que o paciente possuía agenesia dos elementos 12 e 22, tornando-se necessária a reanatomização dos dentesanteriores. Inicialmente ocorreu o planejamento digital, seguido pelo enceramento diagnóstico. Foi realizado em consulta única: cirurgia periodontal pela técnica "flapless" para conquista de espaço protético; confecção dos preparos para facetas; moldagem com silicona de adição; e confecção de múltiplos provisórios em resina bisacrilica. Na consulta de cimentação, as peças foram tratadas comácido fluorídrico 5% por 20s; silanizadas com Relyxceramic primer (3M ESPE), submetidas ao tratamento térmico; e banho ultrassônico. O sistema adesivo utilizado foi o Single Bond (3M ESPE) associado ao RelyxVenner (3M ESPE). Imediatamente a cimentação foi realizado um ajuste oclusal. Após 14 dias o paciente retornou para uma nova consulta de acompanhamento, na qual foi realizada mais um ajuste oclusal, e relatou total satisfação com o tratamento realizado.